Age influences magnitude but not duration of response to levodopa.
نویسندگان
چکیده
منابع مشابه
Age influences magnitude but not duration of response to levodopa.
Following an all-night fast, 45 patients with Parkinson's disease were examined using certain motor items present in the United Parkinson's Disease Rating Scale. All were given a single tablet of carbidopa 25 mg and levodopa 250 mg and re-examined 90 minutes later. In addition to this evaluation, 23 of these patients underwent further scoring over a 4-hour period. A significant negative correla...
متن کاملEntacapone potentiates the long-duration response but does not normalize levodopa-induced molecular changes.
Coadministration of entacapone with levodopa attenuates motor complications in experimental models of Parkinson's disease. The mechanisms underlying entacapone effects are unknown. We investigated the effect of entacapone, on: long-duration response (LDR) to levodopa, levodopa-induced postsynaptic pharmacodynamic mechanisms and molecular changes in hemiparkinsonian rats. 6-Hydroxydopamine-unila...
متن کاملAge Influences Likelihood of Pancreatic Cancer Treatment, but not Outcome
Background Pancreatic cancer (PanCA) is predominantly diagnosed in elderly patients; nevertheless, a significant number of young patients are affected. We hypothesized more aggressive treatment of young PanCA patients would result in better overall survival (OS). Methods A retrospective review of our institutional cancer database identified subjects for inclusion. Age 50 years was selected to...
متن کاملAnaesthesia, not number of sessions, influences the magnitude and duration of an aHF-rTMS in dogs
BACKGROUND Currently, the rat has been a useful animal model in brain stimulation research. Nevertheless, extrapolating results from rodent repetitive Transcranial Magnetic Stimulation (rTMS) research to humans contains several hurdles. This suggests the desperate need for a large animal model in translational rTMS research. The dog would be a valid choice, not only due to the fact that humans ...
متن کاملDuration of the initial TCR stimulus controls the magnitude but not functionality of the CD8+ T cell response
CD8+ T cells only require a brief stimulation with antigen in vitro to divide and differentiate into effector and memory cells upon transfer in vivo. The efficiency of clonal expansion and the functional characteristics of memory cells derived from briefly stimulated cells are poorly defined. We developed a system that allowed us to examine programming entirely in vivo. This was achieved by rap...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Neurology, Neurosurgery & Psychiatry
سال: 1993
ISSN: 0022-3050
DOI: 10.1136/jnnp.56.1.65